The Skinny on Sugar Substitutes

I remember my first conscious exposure to artificial sweeteners. A friend in college baked an entire batch of cookies with a calorie-free sugar substitute and offered me one. My reaction: I can eat ten cookies and not consume any sugar? Bring ’em on!

A few years later, I shifted to the other extreme—avoiding artificial sweeteners at all costs—after a nutritionist told me that drinking a diet coke was akin to sewing the seeds of cancer in my body.

But the recent hype around Splenda prompted me to question my all-or-nothing outlook.

The average American consumes 15 to 20 percent of their daily calories from refined sugar, twice the recommended amount, according to a nutrition study at Tufts University. Can substituting some of that refined sugar for some blood-sugar-spike-free sweeteners be that bad in the bigger picture?

I decided to do some investigating to find out the differences among artificial sweeteners. Is there any real proof that they’re harmful? Perhaps modern advances actually have resulted in a sweetener that will let me have my cake and skinny jeans, too.

What exactly is an artificial sweetener?
“[Sweeteners] are made in a laboratory based off chemicals. Nothing actually comes from nature,” says Lindsay Segal, a graduate student in the physician assistant program at Samuel Merritt College in Oakland. “The body hasn’t seen many of these chemicals before—because it shouldn’t—so you’re introducing things into your body that pretty much are not meant to be there.”

Though different sweeteners have different make-ups, all are meant to be a substitute for sugar and sweeten food and drinks without the calories.

They can’t be sold without an approval from the Food and Drug Administration, which regulates and studies food additives for extended periods of time, and has approved five such sweeteners: saccharin, aspartame, sucralose, acesulfame k, and neotame. The last two are rarely used in the U.S. Image source: Joe Pitz

Saccharin
Brand names: Sweet’N Low, Sugar Twin, Necta Sweet
Maximum daily intake considered safe: About nine to twelve packets of sweetener, according to the Mayo Clinic
Where you find it: Hot chocolate mixes, candies, sugar-free syrups
Numbers: 4 calories, 1 carb per pack

This is the one that caused all the hoopla about cancer a decade ago—you know, the pink packets sporting the warning label we were all afraid of: “This product contains saccharin, which has been determined to cause cancer in laboratory animals.” The additive was originally used in diet sodas, though it’s mostly been replaced by aspartame and sucralose (a.k.a Splenda) nowadays. I’ve found it on the label of some prepared foods, medicines, sugar-free gum, and, of course, on the table at my local breakfast spot—in the little pink packs next to the sugar. And whatever happened to the cancer scare? “The bladder tumors seen in rats are due to a mechanism not relevant to humans,” says the FDA. Somehow that doesn’t eliminate the spooky factor for me.

Aspartame
Brand names: NutraSweet and Equal
Maximum daily intake considered safe: Around eighteen to nineteen cans of diet soda
Where you find it: Diet soda, cereals, sugar-free ice cream, yogurt
Numbers: 3.65 calories, one carb per pack

Most foods you see in the supermarket with bright letters reading “sugar-free!” or “low-calorie!” use this in place of sugar. Sounds great, but there’s a little more to it.

“Aspartame is partially broken down into methanol in the small intestine,” says Segal.

Methanol is fine in small doses, she says, since most of it is absorbed and broken down into formaldehyde and then formic acid—“two things that are okay in our bodies,” according to Segal. However, in higher doses, they’re not. “If there’s too much formaldehyde, the body can’t process it, and some turns toxic,” she says. “This stops a key process in how cells get their nutrients. They stop getting an adequate oxygen supply which, in turn, can end up killing the cell.”

The FDA admits that this is true, but maintains that recommended amounts don’t pose any risk of reaching these harmful levels. In fact, the recommended amounts are one hundred times less than anything that could cause damage. But I’m still not sold on the whole formaldehyde-in-my-brain thing.

24 readers liked this story.
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09.16.2011
Doe Booker
yes, I agree phony sweeteners scare me. Just because a product is made by a company, does not mean it is safe or good for humans to eat every day. Like someone mentioned a food is processed with chemicals and yes your body will figure out what to do with it (urine/feces) or get absorbed and create havoc with your body system.
09.01.2010
Libby Dines
I might have 2 sodas or vitamin water a month, so I don't worry about that, but I do put Splenda in my coffee, and I have 2 cups of that most days. I have actually been thinking that I would just switch to actual sugar. It seems like that small amount wouldn't be bad, and might be worth it to go more natural!
08.29.2010
Archangel
if you want less calories ,just use less sugar or as I do also use unrefined brown sugar or honey......natural products are best IIt`s like butter , dont use chemical spreads , use less butter , you cant beat natural products
08.28.2010
Erik
"Something that just slips through our bodies undigested because the body doesn’t know what it is” (Sucralose) is not bad. It is very natural, although it is not relevant to humans. Animals that eat from the ground get also sand or fine gravel into their body. The digestive tract doesn't recognize it and it leaves the body at the other side without problems. Also hair and teeth of their prey leave their body untouched. Stevia is not as natural as you think. Because it is a rather fragile plant, for economical reasons it is not grown in fields, not even in soil. They come from greenhouse cultivation where they are grown with hydroponic culture. So the plants are protected from weather changes, insect plagues, ... But "hydroponic culture" means growing plants without soil but in sand or vermiculite or other granular material, using a liquid solution of chemical nutrients to feed them. But if you want, you can grow Stevia in your own room at the window.
08.15.2009
Ro
I am VERY sensitive to Aspartame. I wish things with Splenda were more widely avaiable, especially at commercial food facilities. What happened to Coke's cola with Stevia? I heard it was coming and then it just seemed to go poof. If they don't make it available at food service facilities, however (as with Splenda), it will be of little use to many of us. (I am a Type II Diabetic and I usually stick to unsweet ice tea due to the Aspartame problem.) Are you paying attention soft drink manufacturers? Oh, well, probably not!
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